Ligand id: 2890

Name: suvorexant

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 80.29
Molecular weight 450.16
XLogP 4.24
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Suvorexant is approved for the treatment of insomnia.
Mechanism Of Action and Pharmacodynamic Effects
Orexin signalling is essential for the stability of the arousal state across many species [2-3] and disruption of this system plays a role in sleep/wake disorders where the arousal state becomes unstable. Suvorexant antagonises the effect of endogenous orexins A and B at the orexin OX1 and OX2 receptors [1,4] and effectively switches off wakefulness, leading to improved sleep maintenance.