ibandronic acid

Ligand id: 3059

Name: ibandronic acid

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 5
Rotatable bonds 9
Topological polar surface area 158.15
Molecular weight 319.09
XLogP -2.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A bisphosphonate drug, used in the treatment and prevention of osteoporosis in post-menopausal women.
In the EU, marketing authorisation has been withdrawn at the request of the manufacturer.
Mechanism Of Action and Pharmacodynamic Effects
Like all members of the bisphosphonate drug family, ibandronate prevents the breakdown of bone by osteoclasts. So, in patients at risk of osteoporosis, this treatment increases total bone amount and bone strength, with the benefit of decreasing the risk of bone fracture.