N-methyl scopolamine

Ligand id: 316

Name: N-methyl scopolamine

Abbreviated name: NMS

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 59.06
Molecular weight 318.17
XLogP 2.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as an adjunctive therapy in the treatment of peptic ulcers, and to treat nausea and vomiting caused by motion sickness. The 1953 US FDA approval was for a formulation containing methscopolamine bromide. There is no EU-wide EMA approval for use of this drug. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Muscarinic receptor antagonist in the vomiting centre, part of the parasympathetic nervous system.
External links