cinacalcet

Ligand id: 3308

Name: cinacalcet

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: cinacalcet

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 12.03
Molecular weight 357.17
XLogP 9.81
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of secondary hyperparathyroidism in chronic kidney disease, and for the treatment of hypercalcemia in patients with parathyroid cancer.
Mechanism Of Action and Pharmacodynamic Effects
Cinacalcet potentiates the action of extracellular calcium by lowering the threshold for CaSR activation. This effect causes inhibition of PTH secretion and production [5-6].