Ligand id: 34

Name: aripiprazole

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View more information in the IUPHAR Pharmacology Education Project: aripiprazole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 44.81
Molecular weight 447.15
XLogP 4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Atypical antipsychotic used in the treatment of schizophrenia and bipolar disorder and to control irritability in autistic patients. The first generic versions of the drug were approved by the FDA in April 2015.
Mechanism Of Action and Pharmacodynamic Effects
Aripiprazole's antipsychotic activity is likely due to a combination of antagonism at dopamine D2 receptors in the mesolimbic pathway and serotonin 5-HT2A receptors in the frontal cortex.