buspirone

Ligand id: 36

Name: buspirone

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: buspirone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 69.64
Molecular weight 385.25
XLogP 2.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Buspirone is used in the management of anxiety disorders
Mechanism Of Action and Pharmacodynamic Effects
Buspirone binds to and inhibits firing of serotonin 5-HT1A receptors and blocks presynaptic dopamine D2 receptors. This combined action suppresses serotonergic activity and enhances noradrenergic and dopaminergic activity.