levodopa

Ligand id: 3639

Name: levodopa

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 4
Rotatable bonds 3
Topological polar surface area 103.78
Molecular weight 197.07
XLogP -2.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of Parkinson's disease.
Mechanism Of Action and Pharmacodynamic Effects
Levodopa is the precursor of neurotransmitter dopamine. In Parkinson's disease levels of dopamine are significantly decreased, therefore supplementation of dopamine levels with levodopa means that a small percentage of the drug crosses the blood-brain barrier and is decarboxylated to dopamine which stimulates dopaminergic receptors.