Synonyms: decapeptide I | ICI 118630 | Zoladex®
goserelin is an approved drug (FDA (1989))
Compound class:
Peptide or derivative
Comment: Goserelin is a synthetic analogue of the decapeptide, gonadotropin releasing hormone (GnRH). It is known as a 'superagonist'.
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No information available. |
Summary of Clinical Use |
Goserelin has many clinical applications, including treatment of hormone-sensitive cancers of the breast and prostate, treatment of certain benign gynaecological disorders, treatment of precocious puberty, and is used in fertility treatments. |
Mechanism Of Action and Pharmacodynamic Effects |
Treatment with goserelin disrupts the normal feed-back control of the hypothalamic-pituitary-gonadal axis and results in down-regulation of testosterone and estrogen production. |