histrelin

Ligand id: 3884

Name: histrelin

Structure and Physico-chemical Properties

2D Structure
No information available.
Summary of Clinical Use
Histrelin is used to treat hormone-sensitive prostate cancers and uterine fibroids. The drug is also effective in treating precocious puberty in children.
Mechanism Of Action and Pharmacodynamic Effects
Histrelin acetate is a 9 amino acid analog of gonadotropin-releasing hormone (GnRH). The drug activates GnRH receptors in pituitary gonadotrophs, which release the gonadotropins LH and FSH. Sustained activation of GnRH receptors leads to their desensitisation and levels of LH and FSH fall, and the levels of sex steroids remains low.
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