Ligand id: 40

Name: eletriptan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 61.55
Molecular weight 382.17
XLogP 4.61
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of migraine.
Mechanism Of Action and Pharmacodynamic Effects
Eletriptan has high affinity for several subtypes of the serotonin 5-HT1 (specifically 5-HT1B, 1D and 1F). Eletriptan works by causing either drug-induced vasoconstriction of intracranial blood vessels and/or inhibition of pro-inflammatory neuropeptide release from sensory nerve endings in the trigeminal system.