Ligand id: 4172

Name: dantrolene

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 118.05
Molecular weight 314.07
XLogP 2.72
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Dantrolene is a mucle relaxant used to treat patients suffering malignant hyperthermia crises, and may be used peri-operatively in these individuals to prevent crisis.
Mechanism Of Action and Pharmacodynamic Effects
Dantrolene acts via the ryanodine receptor to decrease intracellular calcium concentration and suppress excitation-contraction coupling in skeletal muscle..