flumazenil

Ligand id: 4192

Name: flumazenil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 64.43
Molecular weight 303.1
XLogP 1.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Flumazenil is used to reverse the sedative effects of benzodiazepine-induced general anesthesia and to treat benzodiazepine overdose.
Mechanism Of Action and Pharmacodynamic Effects
Flumazenil is a benzodiazepine receptor antagonist. This drug reverses the CNS effects of benzodiazepines via competitive inhibition at the benzodiazepine site on the GABA/benzodiazepine receptor complex.