procaine

Ligand id: 4291

Name: procaine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 55.56
Molecular weight 236.15
XLogP 2.02
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as a local anaesthetic in dental surgery.
Mechanism Of Action and Pharmacodynamic Effects
The inhibition of sodium influx through voltage-gated sodium channels in the neuronal cell membrane of peripheral nerves leads to the inhibition of signal conductance. Procaine also binds to or antagonises NMDA receptors, nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
External links