toremifene

Ligand id: 4325

Name: toremifene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 9
Topological polar surface area 12.47
Molecular weight 405.19
XLogP 10.47
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of metastatic breast cancer in post-menopausal women with estrogen-receptor-positive or receptor-unknown tumours. Being investigated for the treatment of prostate cancer [1]. Follow this link to view a list of clinical trials assessing toremifene in prostate cancer, registered with ClinicalTrials.gov.
Mechanism Of Action and Pharmacodynamic Effects
Estrogen receptor modulator. In its use in breast cancer treatment, the antitumour effect is believed to arise from its antiestrogenic effect.
External links