fenfluramine

Ligand id: 4613

Name: fenfluramine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 12.03
Molecular weight 231.12
XLogP 4.88
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This drug was approved as a weight-loss aid, which suppressed appetite for carbohydrates.
Mechanism Of Action and Pharmacodynamic Effects
Dexfenfluramine binds to and inhibits the serotonin reuptake pump causing elevated serotonin levels.This results in elevated serotoninergic transmission in the hypothalamic centres which control feeding behavior, which manifests as a decreased appetite for carbohydrate. The drug also affects the activity of the serotonin 5HT2C receptor [4].