Ligand id: 4798

Name: sertraline

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 12.03
Molecular weight 305.07
XLogP 5.87
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of major depressive disorder (MDD), post traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), panic disorder, premenstrual dysphoric disorder (PMDD), social phobia, premature ejaculation and vascular headaches.
Mechanism Of Action and Pharmacodynamic Effects
Sertraline appears to selectively inhibit the reuptake of serotonin at the presynaptic membrane leading to increased synaptic concentration of serotonin in the CNS leading to enhanced serotonergic neurotransmission.
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