pergolide

Ligand id: 48

Name: pergolide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 44.33
Molecular weight 314.18
XLogP 4.3
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of Parkinson's disease as an adjunctive to levodopa or carbidopa. For this indication the drug's primary molecular targets are the central dopamine receptors.
However, the drug's off-target agonist activity at 5-HT2B receptors appears to have been responsible for unacceptable levels of drug-induced cardiac valve damage [1] which lead to the drug's withdrawal from the US market in 2007.
Mechanism Of Action and Pharmacodynamic Effects
For an overview of the mechanism of action of pergolide, please follow the DrugBank link on the Summary tab of this ligand page.