Ligand id: 4803

Name: methamphetamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 12.03
Molecular weight 149.12
XLogP 3.97
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of ADHD and exogenous obesity.
Mechanism Of Action and Pharmacodynamic Effects
After entering the brain, methamphetamine causes a cascading release of noradrenaline, dopamine and serotonin. Also acts as a monoamine oxidase inhibitor and a dopaminergic and adrenergic reuptake inhibitor.