Ligand id: 4804

Name: amphetamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 26.02
Molecular weight 135.1
XLogP 3.58
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Amphetamine is used to treat narcolepsy and attention deficit disorder with hyperactivity (ADHD)
Mechanism Of Action and Pharmacodynamic Effects
Amphetamine stimulates the release of norepinephrine (noradrenaline) from central adrenergic receptors. Amphetamine may also act as a direct agonist on central serotonin (5-HT) receptors and this is assumed to account for its calming effect.