Ligand id: 4805

Name: pentostatin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 112.13
Molecular weight 268.12
XLogP -1.48
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Anti-cancer chemotherapeutic used to treat hairy-cell leukemia and many other lymphoproliferative malignancies.
Mechanism Of Action and Pharmacodynamic Effects
Pentostatin is an adenosine mimetic which inhibits adenosine deaminase activity and thereby reducing cells' ability to process DNA.
External links