Ligand id: 4813

Name: saquinavir

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 5
Rotatable bonds 16
Topological polar surface area 166.75
Molecular weight 670.38
XLogP 6.48
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of HIV-1 with advanced immunodeficiency, in combination with antiretroviral nucleoside analogues.
Mechanism Of Action and Pharmacodynamic Effects
Inhibits the HIV viral proteinase enzyme preventing cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
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