Ligand id: 4825

Name: zidovudine

Abbreviated name: AZT

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 91.23
Molecular weight 267.1
XLogP -0.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Anti-retroviral used in the treatment of HIV/AIDS.
Mechanism Of Action and Pharmacodynamic Effects
Once phosphorylated into active metabolites zidovudine acvts by inhibiting HIV-1 reverse transcriptase. It is also a weak inhibitor of cellular DNA polymerase α and γ.
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