hydrochlorothiazide

Ligand id: 4836

Name: hydrochlorothiazide

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: hydrochlorothiazide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 135.12
Molecular weight 296.96
XLogP -1.26
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Hydrochlorothiazide is a diuretic used to treat edema and hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Hydrochlorothiazide is an inhibitor of the thiazide-sensitive sodium-chloride symporter (SLC12A3). By reducing the reabsorption of electrolytes from the renal tubules, hydrochlorothiazide increases urinary excretion of water (and electrolytes), thus reducing systemic water load.