Ligand id: 50

Name: quetiapine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 73.6
Molecular weight 383.17
XLogP 3.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of schizophrenia, bipolar I disorder (acute treatment of manic or depressive episodes), and major depressive disorder.
Mechanism Of Action and Pharmacodynamic Effects
Antagonism of D2 receptors in the mesolimbic pathway relieves the positive symptoms of schizophrenia, while antagonism of 5HT2A receptors in the frontal cortex relieves negative symptoms.
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