phentolamine

Ligand id: 502

Name: phentolamine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 47.86
Molecular weight 281.15
XLogP 3.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the diagnosis of pheochromocytoma, and in the treatment of hypertensive crisis.
Mechanism Of Action and Pharmacodynamic Effects
Antagonism of alpha-adrenoceptors by phentolamine leads to muscle relaxation and widening of blood vessels resulting in a decrease in blood pressure.
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