Ligand id: 5094

Name: methyltyrosine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 83.55
Molecular weight 195.09
XLogP -1.47
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Metyrosine is used to treat tumours of the adrenal gland known as pheochromocytoma. These tumours over-produce catecholamines and thereby cause hyperstimulation of the sympathetic nervous system.
Mechanism Of Action and Pharmacodynamic Effects
It is hypothesised that metyrosine disrupts the synthesis of catecholamines by acting as an inhibitor of tyrosine hydroxylase, with in vivo human results to support this hypothesis [1].