acadesine

Ligand id: 5133

Name: acadesine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 5
Rotatable bonds 3
Topological polar surface area 156.85
Molecular weight 258.1
XLogP -2.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
It is postulated that activation of AMPK may have clinical potential for correcting defects in the insulin signaling cascade in patients with type 2 diabetes [5,7]. There are no active clinical trials registered on ClinicalTrials.gov (May 2014)
Mechanism Of Action and Pharmacodynamic Effects
5' AMP-activated protein kinase (AMPK) is a trimeric protein complex containing an α, a β, and a γ subunit. In humans there are genes for 2 α, 2 β and 3 γ protein isoforms. AMPK activation regulates many metabolic pathways, including hepatic ketogenesis, cholesterol synthesis, lipogenesis [3], triglyceride synthesis, adipocyte lipolysis, skeletal muscle fatty acid oxidation [4], and is potentially involved in insulin secretion and contraction-induced glucose uptake in muscle cells [2,6].