Ligand id: 5137

Name: anastrozole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 78.29
Molecular weight 293.16
XLogP 1.89
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Anastrozole is indicated in the treatment of breast cancer in post-menopausal women, both as an adjuvant therapy following surgery and in patients with metastatic breast cancer.
Mechanism Of Action and Pharmacodynamic Effects
Estrogen is primarily synthesized by conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues. Aromatase inhibition therefore, leads to a decrease in estrogen levels in both serum and cancer tissue. In estrogen-responsive tumors this results in decreased tumor mass and in some women, delayed tumor growth.