Ligand id: 5150

Name: benserazide

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View more information in the IUPHAR Pharmacology Education Project: benserazide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 7
Rotatable bonds 6
Topological polar surface area 148.07
Molecular weight 257.1
XLogP -0.95
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Madopar® which contains benserazide hydrochloride and levodopa is indicated for the treatment of Parkinsonism and restless legs syndrome. Madopar® has been in use in the UK since 2002.
Mechanism Of Action and Pharmacodynamic Effects
Benserazide inhibits peripheral decarboxylation of levodopa to dopamine and results in a build up of dopamine in the brain as dopamine is unable to exit across the blood–brain barrier.
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