metyrapone

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Ligands
metyrapone

Ligand id: 5224

Name: metyrapone

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	3
Topological polar surface area	42.85
Molecular weight	226.11
XLogP	2.1
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Summary
Biological activity
Clinical data
References
Structure

No information available.

No information available.

Summary of Clinical Use
Used as a diagnostic tool for testing of hypothalamic-pituitary function. Also occasionally used in the treatment of Cushing's syndrome.

Summary of Clinical Use

Used as a diagnostic tool for testing of hypothalamic-pituitary function. Also occasionally used in the treatment of Cushing's syndrome.

Mechanism Of Action and Pharmacodynamic Effects
Metyrapone is an inhibitor of the 11-β-hyrdoxylase enzyme, CYP11B1. Inhibition of this enzyme reduces endogenous corticosteroid synthesis in the adrenal gland. This reverses the inhibitory feedback mechanism exerted by cortisol and results in an increase in adrenocorticotropic hormone (ACTH) production by the pituitary.

Mechanism Of Action and Pharmacodynamic Effects

Metyrapone is an inhibitor of the 11-β-hyrdoxylase enzyme, CYP11B1. Inhibition of this enzyme reduces endogenous corticosteroid synthesis in the adrenal gland. This reverses the inhibitory feedback mechanism exerted by cortisol and results in an increase in adrenocorticotropic hormone (ACTH) production by the pituitary.