Ligand id: 5239

Name: paracetamol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 49.33
Molecular weight 151.06
XLogP 1.08
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to relieve pain and reduce fever. The therapeutic effects of paracetamol are similar to those of the aspirin-like compounds, but it does not have any anti-inflammatory or antiplatelet effects and does not irritate the lining of the stomach.
Mechanism Of Action and Pharmacodynamic Effects
Acting primarily in the CNS, paracetamol inhibits both isoforms of cyclooxygenase, COX-1 and COX-2 enzymes involved in prostaglandin (PG) synthesis, possibly by an indirect mechanism.
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