orlistat

Ligand id: 5277

Name: orlistat

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 24
Topological polar surface area 81.7
Molecular weight 495.39
XLogP 10.26
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Preventing the absorption of fats from the human diet, thereby reducing caloric intake in obesity.
Mechanism Of Action and Pharmacodynamic Effects
Reversible lipase inhibitor. Gastric and pancreatic lipase enzymes are inhibited via formation of a covalent bond with the active serine residue site. These inactivated enzymes are then unable to hydrolyse dietary fat into absorbable free fatty acids and monoglycerides.
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