cisplatin   Click here for help

GtoPdb Ligand ID: 5343

Synonyms: Platinol®
Approved drug
cisplatin is an approved drug (FDA (1978))
Compound class: Inorganic
Comment: Cisplatin is a platinum-based chemotherapy drug in the same class as carboplatin and oxaliplatin. Its main action is as an alkylating agent (see Clinical Data tab for further details).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
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Summary of Clinical Use Click here for help
Cisplatin is used to treat various types of cancer, including metastatic testicular tumors, metastatic ovarian tumors, lymphomas, germ cell tumours and advanced bladder cancer.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Cisplatin acts in several ways to interfere with DNA/RNA synthesis and replication and cell division, and to cause DNA mutation and damage, all of which lead to cell death/apoptosis. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.