Ligand id: 536

Name: isoprenaline

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 72.72
Molecular weight 211.12
XLogP 0.81
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of heart block, asthma and chronic bronchitis. There is no information regarding approval for medical use of isoprenaline on the US FDA or on the European Medicines Agency (EMA) websites. Individual national agencies may have granted marketing approval.
Mechanism Of Action and Pharmacodynamic Effects
Agonism of β-adrenoceptors, leads to stimulation of intracellular adenyl cyclase, and increased levels of cyclic AMP. This results in relaxation of bronchial smooth muscle and the inhibition of hypersensitivity mediator release from mast cells.