Ligand id: 5459

Name: varenicline

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 37.81
Molecular weight 211.11
XLogP 1.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as an aid to smoking cessation.
Mechanism Of Action and Pharmacodynamic Effects
Inhibits the binding of nicotine to the α4β2 nicotinic acetylcholine receptor, and exerts mild agonistic activity at the receptor, therefore easing nicotine withdrawal symptoms.
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