etomidate

Ligand id: 5463

Name: etomidate

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 44.12
Molecular weight 244.12
XLogP 3.87
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Etomidate is used with other drugs to induce general anesthesia for short surgeries.
Mechanism Of Action and Pharmacodynamic Effects
Etomidate prolongs the thalamic post-synaptic inhibitory effect of GABA by binding to a distinct site associated with the Cl- ionophore at the GABAA receptor.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.