pentobarbitone

Ligand id: 5480

Name: pentobarbitone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 75.27
Molecular weight 226.13
XLogP 2.08
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the short-term treatment of insomnia.
Mechanism Of Action and Pharmacodynamic Effects
Binds at a distinct binding site associated with the Cl- ionophore at the GABAA receptor, which increases the length of time for which the ionophore is open, and in turn prolonging the post-synaptic inhibitory effect of GABA in the thalamus.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.
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