Ligand id: 5484

Name: pregabalin

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View more information in the IUPHAR Pharmacology Education Project: pregabalin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 63.32
Molecular weight 159.13
XLogP 1.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat generalised anxiety disorder (GAD) and in the management of neuropathic pain associated with diabetic peripheral neuropathy or spinal chord injury, and post herpetic neuralgia. Also used in the management of fibromyalgia and as an adjunctive therapy for partial onset seizures.
Mechanism Of Action and Pharmacodynamic Effects
Like gabapentin, pregabalin likely acts, at least in part, via inhibition of the α2δ subunit (CACNA2D1, P54289) of the VGCC. Some evidence exists to support the hypothesis that compounds such as pregabalin and gabapentin don't actually block presynaptic calcium channels, but rather exert an inhibitory effect on the re-cycling of the channels from endosomal pools back to the plasma membrane via interaction with intracellular δ subunits [1].
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