foscarnet

Ligand id: 5497

Name: foscarnet

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 104.64
Molecular weight 125.97
XLogP -2.13
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Foscarnet is used to treat cytomegalovirus retinitis in people with AIDS and to treat herpes simplex virus in immunocompromised patients.
Mechanism Of Action and Pharmacodynamic Effects
Foscarnet prevents viral replication by selectively inhibiting the pyrophosphate binding site on virus-specific DNA polymerases. This drug does not affect host cell DNA polymerases at therapeutic concentrations.