Ligand id: 5509

Name: naphazoline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 24.39
Molecular weight 210.12
XLogP 5.01
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Naphazoline is a vasoconstrictor which temporarily reduces eye redness by narrowing swollen blood vessels in the eyes.
Mechanism Of Action and Pharmacodynamic Effects
Agonism of the α-adrenoceptors in the nasal muscosa results in vasoconstriction leading to decreased blood flow and decreased nasal congestion. However, we have been unable to find affinity data for this drug to substantiate its MMOA.
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