carvedilol

Ligand id: 551

Name: carvedilol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 75.74
Molecular weight 406.19
XLogP 4.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of heart failure.
Mechanism Of Action and Pharmacodynamic Effects
Carvedilol blocks β1 and β2 adrenergic receptors (S enantiomer) as well as the α1 adrenergic receptor (R and S enantiomers). Inhibition of the β-ARs decreases heart rate, myocardial contractility, and myocardial oxygen demand and inhibition of the α-AR decreases systemic vascular resistance, with the net effect being reduced strain on the heart. Carvedilol and its metabolites have also been shown to reduce free radical formation, so may help to prevent free radical damage observed in chronic heart failure.