nadolol

Ligand id: 554

Name: nadolol

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: nadolol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 81.95
Molecular weight 309.19
XLogP 1.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of migraine pain, tremor, angina pectoris and hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Antagonist of beta-adrenergic receptors which inhibits the effects of adrenaline and noradrenaline at the vascular smooth muscle, decreasing heart rate, cardiac output and systolic and diastolic blood pressure. Antagonism of the beta-2 adrenoceptors in bronchial smooth muscle causes vasoconstriction. Production of angiotensin II and aldosterone is inhibited through inhibition of renin production.
External links