ephedrine

Ligand id: 556

Name: ephedrine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 32.26
Molecular weight 165.12
XLogP 2.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Ephedrine may be used for temporary relief of shortness of breath, chest tightness, and wheezing due to bronchial asthma. Stimulatory effects in the central nervous system have indicated used of ephedrine in the treatment of narcolepsy and depression and this drug is often used as an illicit stimulant and appetite suppressant. No information regarding marketing approval for use in humans is available for this drug on the US FDA or European Medicines Agency websites.
Mechanism Of Action and Pharmacodynamic Effects
Ephedrine is a decongestant and bronchodilator which gives symptomatic relief by reducing swelling and causing constriction of blood vessels in the nasal passages, as well as relaxing the lung airways. The mechanism of action in central nervous system is complex, and best described in the DrugBank link on the Summary tab for this ligand.