salmeterol

Ligand id: 559

Name: salmeterol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 16
Topological polar surface area 81.95
Molecular weight 415.27
XLogP 5.94
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Salmeterol is approved in a fixed-dose inhalation powder formulation with the long-acting β2-adrenergic agonist fluticasone propionate (AirDuo RespiClickTM) for the treatment of asthma.
Mechanism Of Action and Pharmacodynamic Effects
Causes stimulation of beta-2 adrenoceptors in the lung leading to relaxation of bronchial smooth muscle, bronchodilation and increased bronchial airflow.
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