terbutaline

Ligand id: 560

Name: terbutaline

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 72.72
Molecular weight 225.14
XLogP 0.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the prevention and reversal of bronchospasm in reversible, obstructive airway disease and management of bronchospasm associated with bronchitis and emphysema. Also used for the inhibition of uterine contractions in cases of premature labour.
Mechanism Of Action and Pharmacodynamic Effects
Stimulates intracellular adenyl cyclase which results in increased levels of cAMP resulting in bronchial smooth muscle relaxation and inhibition of the release of mediators of immediate hypersensitivity from mast cells.
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