timolol

Ligand id: 565

Name: timolol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 107.98
Molecular weight 316.16
XLogP 0.25
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Timolol is available clinically in two forms: an oral form, which is used to treat hight blood pressure and in the prevention of heart attacks, and an opthalmic formulation which is used to treat open angle and secondary glaucoma.
Mechanism Of Action and Pharmacodynamic Effects
β1 and β2 adrenoceptor antagonist. Blockade of β1 receptors results in a decrease in systolic and diastolic blood pressure, while β2 blockade results in an increase in peripheral vascular resistance.
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