barasertib-hQPA

Ligand id: 5663

Name: barasertib-hQPA

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 14
Topological polar surface area 128.29
Molecular weight 507.24
XLogP 3.58
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This drug is in Phase I clinical trial in patients with advanced solid tumors [6], although its use is limited by the need for continuous i.v. infusion. To overcome this limitation, a nanoparticle formulation of AZD1152-hQPA known as AZD2811 has been developed [3] and is being evaluated in early stage clinical trials for AML and some advanced solid tumours (see NCT03217838, NCT03366675 and NCT02579226 [1] for example) .