alvocidib

Ligand id: 5680

Name: alvocidib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 90.23
Molecular weight 401.1
XLogP 1.74
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Alvocidib is an experimental compound being investigated as an anti-neoplastic agent. For more information regarding current clinical trials testing alvocidib visit www.clinicaltrials.gov.
Mechanism Of Action and Pharmacodynamic Effects
Alvocidib is a CDK kinase inhibitor [1,7] which causes cell-cycle arrest and subsequent apoptosis of cancer cells [2,4].