beclometasone dipropionate

Ligand id: 5894

Name: beclometasone dipropionate

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 106.97
Molecular weight 520.22
XLogP 2.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the management of asthma symptoms and the treatment of allergic rhinitis.
Mechanism Of Action and Pharmacodynamic Effects
Agonist of the glucocorticoid receptor (GR). By binding to this receptor, inhibition of leukocyte filtration at the site of inflammation occurs, along with interference of the function of inflammatory mediators and suppression of the humoral immune responses. Beclometasone dipropionate, once converted to its active form beclometasone, induces an antiinflammatory response.