Ligand id: 591

Name: olmesartan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 154.34
Molecular weight 558.22
XLogP 7.86
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Inhibition of the binding of angiotensin II to the AT1 receptor by olmesartan inhibits the AT1-mediated vasocontrictive and aldosterone-secreting effects of angiotensin II and results in a decrease in vascular resistance and blood pressure.
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